Peripheral neuropathy refers to damage of the peripheral nerves, which branch out from the brain and spine to the rest of the body. It typically begins with pain, numbness, tingling, burning or weakness in the feet, legs and/or hands, and may progress to more serious conditions such as ulcers, pain and loss of sensation. Numbness is especially dangerous, as patients sometimes do not detect an injury until the damage is so pervasive that the limb requires amputation. Peripheral neuropathy may develop because of a nerve disease or as a side effect of an illness or medication. Some of the procedures used to treat peripheral neuropathy are nerve decompression and partial joint denervation to relieve foot, ankle, knee and leg pain.